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Article

Dwarfism and dysregulated proliferation in mice overexpressing the MYC antagonist MAD1.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1999

Quéva C, McArthur G A, Ramos L S, Eisenman R N

Abstract excerpt

The four members of the MAD family are bHLHZip proteins that heterodimerize with MAX and act as transcriptional repressors. The switch from MYC-MAX complexes to MAD-MAX complexes has been postulated to couple cell-cycle arrest with differentiation. The ectopic expression of Mad1 in transgenic mice led to early postnatal lethality and dwarfism and had a profound inhibitory effect on the proliferation of the...

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Source

Identifiers

PMID: 10616903

Genes

MAX
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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