Article
Idiotypic immunization induces immunity to mutated p53 and tumor rejection.
Nature medicine - 1 Jun 1998
Ruiz P J, Wolkowicz R, Waisman A, Hirschberg D L, Carmi P, Erez N, Garren H, Herkel J, Karpuj M, Steinman L, Rotter V, Cohen I R
Abstract excerpt
The p53 molecule might serve as a common tumor-associated antigen, as the tumor suppressor gene p53 is mutated and the p53 protein is often over-expressed in tumor cells. We report that effective immunity to p53 can be induced through an idiotypic network by immunization of mice with a monoclonal antibody (PAb-240) specific for mutated p53, or with a peptide derived from the complementarity determining region...
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