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Article

CD4+ T cell responses to self- and mutated p53 determinants during tumorigenesis in mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2000

Fedoseyeva E V, Boisgérault F, Anosova N G, Wollish W S, Arlotta P, Jensen P E, Ono S J, Benichou G

Abstract excerpt

We analyzed CD4+ T helper responses to wild-type (wt) and mutated (mut) p53 protein in normal and tumor-bearing mice. In normal mice, we observed that although some self-p53 determinants induced negative selection of p53-reactive CD4+ T cells, other p53 determinants (cryptic) were immunogenic. Ne...

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Share to CD4-Positive T-Lymphocytes
Share to Epitopes, T-Lymphocyte
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred BALB C

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Source

Identifiers

PMID: 10820239
DOI: 10.4049/jimmunol.164.11.5641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10820239-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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