Article
Mapping and ranking of potential cytotoxic T epitopes in the p53 protein: effect of mutations and polymorphism on peptide binding to purified and refolded HLA molecules.
European journal of immunology - 1 Jun 1995
Gnjatic S, Bressac-de Paillerets B, Guillet J G, Choppin J
Abstract excerpt
In many cancer cells, the p53 gene displays point mutations that result in stabilization and accumulation of the p53 protein. Therefore, p53 peptides could be presented to the immune system by tumor cells; thus, p53 might be a suitable target antigen for developing an immunotherapy against tumors...
Topics
- Amino Acid Sequence
- Binding Sites
- Cell Line
- Epitopes
- HLA-A Antigens
- HLA-B Antigens
- Molecular Sequence Data
- Mutation
- Peptide Mapping
- Polymorphism, Genetic
- T-Lymphocytes, Cytotoxic
- Tumor Suppressor Protein p53