Article
Split T cell tolerance against a self/tumor antigen: spontaneous CD4+ but not CD8+ T cell responses against p53 in cancer patients and healthy donors.
PloS one - 1 Jan 2011
Tsuji Takemasa, Matsuzaki Junko, Ritter Erika, Miliotto Anthony, Ritter Gerd, Odunsi Kunle, Old Lloyd J, Gnjatic Sacha
Abstract excerpt
Analyses of NY-ESO-1-specific spontaneous immune responses in cancer patients revealed that antibody and both CD4(+) and CD8(+) T cell responses were induced together in cancer patients. To explore whether such integrated immune responses are also spontaneously induced for other tumor antigens, we have evaluated antibody and T cell responses against self/tumor antigen p53 in ovarian cancer patients and healthy...
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