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Article

Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.

Journal of medicinal chemistry - 25 Aug 2005

O'Meara Jeff A, Yoakim Christiane, Bonneau Pierre R, Bös Michael, Cordingley Michael G, Déziel Robert, Doyon Louise, Duan Jianmin, Garneau Michel, Guse Ingrid, Landry Serge, Malenfant Eric, Naud Julie, Ogilvie William W, Thavonekham Bounkham, Simoneau Bruno

Abstract excerpt

A series of novel 8-substituted dipyridodiazepinone-based inhibitors were investigated for their antiviral activity against wild type human immunodeficiency virus (HIV-1) and the clinically prevalent K103N/Y181C mutant virus. Our efforts have resulted in a series of benzoic acid analogues that are potent inhibitors of HIV-1 replication against a panel of HIV-1 strains resistant to non-nucleoside reverse...

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PMID: 16107158
DOI: 10.1021/jm050255t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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