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Article

Novel Acylguanidine-Based Inhibitor of HIV-1.

Journal of virology - 15 Oct 2016

Mwimanzi Philip, Tietjen Ian, Miller Scott C, Shahid Aniqa, Cobarrubias Kyle, Kinloch Natalie N, Baraki Bemuluyigza, Richard Jonathan, Finzi Andrés, Fedida David, Brumme Zabrina L, Brockman Mark A

Abstract excerpt

UNLABELLED: The emergence of transmissible HIV-1 strains with resistance to antiretroviral drugs highlights a continual need for new therapies. Here we describe a novel acylguanidine-containing compound, 1-(2-(azepan-1-yl)nicotinoyl)guanidine (or SM111), that inhibits in vitro replication of HIV-1, including strains resistant to licensed protease, reverse transcriptase, and integrase inhibitors, without major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27512074
DOI: 10.1128/JVI.01107-16
PMCID: PMC5044834

Genes

BST2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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