Article
SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2.
Antimicrobial agents and chemotherapy - 1 Feb 2001
Buckheit R W, Watson K, Fliakas-Boltz V, Russell J, Loftus T L, Osterling M C, Turpin J A, Pallansch L A, White E L, Lee J W, Lee S H, Oh J W, Kwon H S, Chung S G, Cho E H
Abstract excerpt
We have identified and characterized a potent new nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) that also is active against HIV-2 and which interferes with virus replication by two distinct mechanisms. 1-(3-Cyclopenten-1-yl)methyl-6-(3,5-dimethylbenzoyl)-5-ethyl-2,4-pyrimidinedione (SJ-3366) inhibits HIV-1 replication at concentrations of approximately 1...
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