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Article

Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death.

Biochemical and biophysical research communications - 29 Sept 2006

Kamata Masakazu, Wu Raymond P, An Dong Sung, Saxe Jonathan P, Damoiseaux Robert, Phelps Michael E, Huang Jing, Chen Irvin S Y

Abstract excerpt

Viral protein R (Vpr), one of the human immunodeficiency virus type 1 (HIV-1) accessory proteins, contributes to multiple cytopathic effects, G2 cell cycle arrest and apoptosis. The mechanisms of Vpr have been intensely studied because it is believed that they underlie HIV-1 pathogenesis. We here report a cell-based small molecule screen on Vpr induced cell death in the context of HIV-1 infection. From the screen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16904642
DOI: 10.1016/j.bbrc.2006.07.158
PMCID: PMC1761125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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