Article
Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer.
Cancer research - 1 Jun 1998
Bouvet M, Ellis L M, Nishizaki M, Fujiwara T, Liu W, Bucana C D, Fang B, Lee J J, Roth J A
Abstract excerpt
Recent studies have indicated that angiogenesis may be regulated, in part, by p53 tumor suppressor gene function. We hypothesized that wild-type p53 replacement would down-regulate vascular endothelial growth factor (VEGF) expression and inhibit angiogenesis. KM12L4 and SW620, human colon cancer...
Topics
- Adenoviridae
- Colonic Neoplasms
- Down-Regulation
- Endothelial Growth Factors
- Gene Expression Regulation, Neoplastic
- Gene Transfer Techniques
- Genes, p53
- Genetic Therapy
- Humans
- Lymphokines
- Mutation
- Neovascularization, Pathologic
- RNA, Messenger
- Tumor Cells, Cultured