Article
Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.
Cancer research - 15 Oct 1995
Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T, Kerbel R S
Abstract excerpt
The growth of solid tumors in vivo beyond 1-2 mm in diameter requires induction and maintenance of an angiogenic response. This can occur through the release of various angiogenic growth factors from tumor cells. One such factor is vascular endothelial growth factor/vascular permeability factor (...
Topics
- Alkyl and Aryl Transferases
- Animals
- Cell Division
- Endothelial Growth Factors
- Endothelium, Vascular
- Enzyme Inhibitors
- Farnesyltranstransferase
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- In Vitro Techniques
- Lymphokines
- Mutation
- Neovascularization, Pathologic
- Oligopeptides
- Protein Processing, Post-Translational
- Proto-Oncogene Proteins p21(ras)
- RNA, Messenger