Article
Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998
Okada F, Rak J W, Croix B S, Lieubeau B, Kaya M, Roncari L, Shirasawa S, Sasazuki T, Kerbel R S
Abstract excerpt
Targeted disruption of the single mutant K-ras allele in two human colorectal carcinoma cell lines (DLD-1 and HCT-116) leads to loss of tumorigenic competence in nude mice with retention of ability to grow indefinitely in monolayer culture. Because expression of the mutant K-ras oncogene in these...
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