Article
Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells.
BMC cancer - 7 May 2013
Yamagishi Naoko, Teshima-Kondo Shigetada, Masuda Kiyoshi, Nishida Kensei, Kuwano Yuki, Dang Duyen T, Dang Long H, Nikawa Takeshi, Rokutan Kazuhito
Abstract excerpt
BACKGROUND: Vascular endothelial growth factor-a (VEGF)-targeted therapies have become an important treatment for a number of human malignancies. The VEGF inhibitors are actually effective in several types of cancers, however, the benefits are transiently, and the vast majority of patients who initially respond to the therapies will develop resistance. One of possible mechanisms for the acquired resistance may be...
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