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Article

p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth.

Carcinogenesis - 1 Oct 2016

Hayashi Yoshito, Tsujii Masahiko, Kodama Takahiro, Akasaka Tomofumi, Kondo Jumpei, Hikita Hayato, Inoue Takuya, Tsujii Yoshiki, Maekawa Akira, Yoshii Shunsuke, Shinzaki Shinichiro, Watabe Kenji, Tomita Yasuhiko, Inoue Masahiro, Tatsumi Tomohide, Iijima Hideki, Takehara Tetsuo

Abstract excerpt

Cancer-associated fibroblasts (CAFs) create a microenvironment that contributes to tumor growth; however, the mechanism by which fibroblasts are phenotypically altered to CAFs remains unclear. Loss or mutation of the tumor suppressor p53 plays a crucial role in cancer progression. Herein, we analyzed how the p53 status of cancer cells affects fibroblasts by investigating the in vivo and in vitro effects of loss...

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Identifiers

PMID: 27520561
DOI: 10.1093/carcin/bgw085

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