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Article

Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes.

PloS one - 1 Jan 2016

Thornley Thomas B, Agarwal Krishna A, Kyriazis Periklis, Ma Lingzhi, Chipashvili Vaja, Aker Jonathan E, Korniotis Sarantis, Csizmadia Eva, Strom Terry B, Koulmanda Maria

Abstract excerpt

The innate immune system critically shapes diabetogenic adaptive immunity during type 1 diabetes (T1D) pathogenesis. While the role of tissue-infiltrating monocyte-derived macrophages in T1D is well established, the role of their tissue-resident counterparts remains undefined. We now demonstrate that islet resident macrophages (IRMs) from non-autoimmune mice have an immunoregulatory phenotype and powerfully...

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PMID: 26943809
DOI: 10.1371/journal.pone.0150792
PMCID: PMC4778921

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TLR4

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