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Article

Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations.

Oncogene - 9 Nov 2006

Kjaer S, Kurokawa K, Perrinjaquet M, Abrescia C, Ibáñez C F

Abstract excerpt

In patients with medullary thyroid carcinoma (MTC) and type 2A multiple endocrine neoplasia (MEN2A), mutations of cysteine residues in the extracellular juxtamembrane region of the RET receptor tyrosine kinase cause the formation of covalent receptor dimers linked by intermolecular disulfide bonds between unpaired cysteines, followed by oncogenic activation of the RET kinase. The close proximity to the plasma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16732321
DOI: 10.1038/sj.onc.1209698

Genes

RET
GDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations.PMID 16732321Read ↗

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