Genetic instability, p53 and nm23 mutation and clinicopathological features in rectal carcinoma.

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Article

Genetic instability, p53 and nm23 mutation and clinicopathological features in rectal carcinoma.

Anticancer research - 1 Jan 2000

Indinnimeo M, Cicchini C, Stazi A, Mingazzini P, Caligo M A, Ghimenti C, Bevilacqua G

Abstract excerpt

Defective DNA mismatch repair proteins fail to correct replication errors (RERs). These defects may lead to secondary, mutation of oncogenes and tumor suppressor genes. Microsatellite instability might be a marker of such replication errors. Eighteen rectal tumors were examined to evaluate geneti...

Topics

Adult
Aged
Aged, 80 and over
Female
Genes, p53
Humans
Male
Microsatellite Repeats
Middle Aged
Monomeric GTP-Binding Proteins
Mutation
NM23 Nucleoside Diphosphate Kinases
Nucleoside-Diphosphate Kinase
Polymerase Chain Reaction
Rectal Neoplasms
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 9615752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9615752-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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