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Article

A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases

1 Jul 2025

Abstract excerpt

Neuromuscular diseases such as amyotrophic lateral sclerosis and sarcopenia cause muscle atrophy, which preferentially affects fast-twitch glycolytic myofibers. The mechanisms underlying the susceptibility of fast myofibers to disease remain unclear. To investigate this, we analyzed the transcriptional profiles of myonuclei from denervated muscle fibers. We found that the fast muscle gene program and the...

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PMID: 40632651
DOI: 10.1016/j.celrep.2025.115959

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