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Article

Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype.

Molecular and cellular biology - 1 Jul 2004

Grifone Raphaelle, Laclef Christine, Spitz François, Lopez Soledad, Demignon Josiane, Guidotti Jacques-Emmanuel, Kawakami Kiyoshi, Xu Pin-Xian, Kelly Robert, Petrof Basil J, Daegelen Dominique, Concordet Jean-Paul, Maire Pascal

Abstract excerpt

Muscle fibers show great differences in their contractile and metabolic properties. This diversity enables skeletal muscles to fulfill and adapt to different tasks. In this report, we show that the Six/Eya pathway is implicated in the establishment and maintenance of the fast-twitch skeletal muscle phenotype. We demonstrate that the MEF3/Six DNA binding element present in the aldolase A pM promoter mediates the...

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Identifiers

PMID: 15226428
DOI: 10.1128/MCB.24.14.6253-6267.2004
PMCID: PMC434262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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