Article
Transcriptional control of muscle plasticity: differential regulation of troponin I genes by electrical activity.
Developmental genetics - 1 Jan 1996
Calvo S, Stauffer J, Nakayama M, Buonanno A
Abstract excerpt
Plasticity of the skeletal muscle phenotype can result from the selective repression and activation of gene expression in response to innervation patterns. Motoneurons, eliciting different patterns of depolarization, regulate the contractile properties of the myofibers they innervate by selectively activating expression of genes encoding fiber-type-specific (fast vs. slow) contractile proteins. We have analyzed...
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