Article
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.
Nucleic acids research - 15 Jun 1998
Graubert T A, Hug B A, Wesselschmidt R, Hsieh C L, Ryan T M, Townes T M, Ley T J
Abstract excerpt
The random insertion of transgenes into the genomic DNA of mice usually leads to widely variable levels of expression in individual founder lines. To study the mechanisms that cause variegation, we designed a transgene that we expected to variegate, which consisted of a beta-globin locus control...
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