Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2003

Gaensler Karin M L, Zhang Zemin, Lin Chin, Yang Suya, Hardt Karin, Flebbe-Rehwaldt Linda

Abstract excerpt

The human beta-globin locus has been extensively studied as a model of tissue and developmental stage-specific gene expression. Structural mapping of naturally occurring mutations, including transfection and transgenic studies, and the recent finding of intergenic transcripts have suggested that there are cis-acting sequence elements in the (A)gamma-delta intergenic region involved in regulating gamma- and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Yeast
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, Regulator

Share to Globins

Share to Mice, Transgenic

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 12629213
DOI: 10.1073/pnas.0634132100
PMCID: PMC152300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus.PMID 12629213Read ↗

Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice.Semantic proximity Read ↗

An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domainSemantic proximity Read ↗

Chromatin Structure and Control of β-Like Globin Gene SwitchingSemantic proximity Read ↗

Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity.Semantic proximity Read ↗

Genome architecture of the human beta-globin locus affects developmental regulation of gene expression.Semantic proximity Read ↗

Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.Semantic proximity Read ↗

The role of the -50 region of the human gamma-globin gene in switching.Semantic proximity Read ↗

Regulation of the human α globin gene cluster in transgenic miceSemantic proximity Read ↗

Developmental stage–specific epigenetic control of human β-globin gene expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activationSemantic proximity Read ↗

Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.Semantic proximity Read ↗

An in vivo model for analysis of developmental erythropoiesis and globin gene regulation.Semantic proximity Read ↗

Human globin locus activation region (LAR): role in temporal control.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.