Article
Mono-allelic expression of variegating transgene locus in the mouse.
Transgenic research - 1 Dec 2003
Opsahl Margaret L, Springbett Anthea, Lathe Richard, Colman Alan, McClenaghan Margaret, Whitelaw C Bruce A
Abstract excerpt
We have generated transgenic mice which express an ovine beta-lactoglobulin transgene during lactation. In two transgenic lines, BLG/7 and BLG/45, beta-lactoglobulin protein levels vary between siblings, reflected at the cellular level by a mosaic transgene expression pattern in the mammary tissue that is reminiscent of position effect variegation. To investigate whether this variegating expression profile can be...
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