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Article

An in vivo model for analysis of developmental erythropoiesis and globin gene regulation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2014

McColl Bradley, Kao Betty R, Lourthai Preeyachan, Chan Kasey, Wardan Hady, Roosjen Mark, Delagneau Orane, Gearing Linden J, Blewitt Marnie E, Svasti Saovaros, Fucharoen Suthat, Vadolas Jim

Abstract excerpt

Expression of fetal γ-globin in adulthood ameliorates symptoms of β-hemoglobinopathies by compensating for the mutant β-globin. Reactivation of the silenced γ-globin gene is therefore of substantial clinical interest. To study the regulation of γ-globin expression, we created the GG mice, which carry an intact 183-kb human β-globin locus modified to express enhanced green fluorescent protein (eGFP) from the...

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Identifiers

PMID: 24443374
DOI: 10.1096/fj.13-246637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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