Article
Patterns of loss of heterozygosity at 10q23.3 and microsatellite instability in endometriosis, atypical endometriosis, and ovarian carcinoma arising in association with endometriosis.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Jul 2006
Ali-Fehmi Rouba, Khalifeh Ibrahim, Bandyopadhyay Sudeshna, Lawrence W Dwayne, Silva Elvio, Liao Dezhong, Sarkar Fazlul H, Munkarah Adnan R
Abstract excerpt
Genetic aberrations, such as loss of heterozygosity (LOH) and mutations leading to functional inactivation of the PTEN tumor suppressor gene, located on chromosome 10q23.3, have been shown to be associated with approximately one third of ovarian adenocarcinomas. In addition, microsatellite instability (MSI) leading to the functional inactivation of the PTEN gene has also been reported for ovarian adenocarcinomas...
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