Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.

Abstract excerpt

The major mutational hot spots in human cancers occur at CpG sequences in the p53 gene. It is generally presumed that the majority of mutations at these sites result from the endogenous deamination of methylated cytosine. Using a UvrABC incision method, we have found that cytosine methylation greatly enhances guanine alkylation at all CpG sites in the p53 gene by a variety of carcinogens, including benzo(a)pyrene...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Carcinogens
• Share to CpG Islands