Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma.

doi:10.1002/ijc.21716

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Article

Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma.

International journal of cancer - 15 Apr 2006

Bräuninger Andreas, Schmitz Roland, Bechtel Dörte, Renné Christoph, Hansmann Martin-Leo, Küppers Ralf

Abstract excerpt

Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's lymphoma (HL), represent transformed B cells in nearly all cases. The detection of destructive somatic mutations in the rearranged immunoglobulin (Ig) genes of HRS cells in classical HL indicated that they originate from preapoptotic germinal centre (GC) B cells that lost the capacity to express a high-affinity B-cell receptor...

Topics

B-Lymphocytes
Cell Transformation, Neoplastic
Epstein-Barr Virus Infections
Hodgkin Disease
Humans
Immunoglobulins
Mutation
Reed-Sternberg Cells
Signal Transduction

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PMID: 16385563
DOI: 10.1002/ijc.21716

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