Article
Somatic mutation and memory.
Current opinion in immunology - 1 Apr 1993
Berek C
Abstract excerpt
The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
Topics
- Animals
- Antibody Diversity
- Antibody Formation
- Autoantibodies
- Autoimmune Diseases
- B-Lymphocyte Subsets
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Humans
- Immunization
- Immunologic Memory
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphoid Tissue
- Lymphoma, Follicular
- Mice
- Mutation
- Neoplasm Proteins