Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermutation in antibody affinity maturation.

Current opinion in immunology - 1 Apr 1999

Wabl M, Cascalho M, Steinberg C

Abstract excerpt

By studying the role of mismatch repair in hypermutation at the immunoglobulin loci, the field of antibody hypermutation has been integrated into the larger area of DNA repair. Trans-acting factors - Ku70, Ku80 and possibly SWAP-70 - have been identified for the temporally related but not mechanistically related immunoglobulin heavy-chain class-switch.

Topics

Animals
Antibody Affinity
DNA Repair
Genes, Immunoglobulin
Humans
Immunoglobulin Class Switching
Immunoglobulin Heavy Chains
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10322147
DOI: 10.1016/s0952-7915(99)80031-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermutation in antibody affinity maturation.PMID 10322147Read ↗

DNA repair in antibody somatic hypermutationSemantic proximity Read ↗

Molecular mechanisms of antibody somatic hypermutation.Semantic proximity Read ↗

The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.Semantic proximity Read ↗

Mismatch repair and immunoglobulin gene hypermutation: did we learn something?Semantic proximity Read ↗

Controlling somatic hypermutation in immunoglobulin variable and switch regions.Semantic proximity Read ↗

The molecular basis of somatic hypermutation of immunoglobulin genes.Semantic proximity Read ↗

AIDing antibody diversity by error-prone mismatch repair.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin genes.Semantic proximity Read ↗

AID and mismatch repair in antibody diversificationSemantic proximity Read ↗

Balancing AID and DNA repair during somatic hypermutation.Semantic proximity Read ↗

Epigenomic Modifications Mediating Antibody MaturationSemantic proximity Read ↗

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AIDSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.