Article
Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging.
Human mutation - 1 Jan 1998
Zhang C, Liu V W, Addessi C L, Sheffield D A, Linnane A W, Nagley P
Abstract excerpt
Seven mtDNA mutations (five base substitutions and two deletions) were studied in skeletal muscle samples of 18 human subjects aged 1 hr to 90 years. Quantitative PCR procedures were applied to determine the incidence (frequency of occurrence) and abundance (percentage of mutant mtDNA out of total mtDNA). The base substitutions, in general, showed a very early onset, three such mutations being detectable in the...
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