Article
Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors.
Mechanisms of ageing and development - 1 Jan 2002
Gerhard Glenn S, Benko Floyd A, Allen R G, Tresini Maria, Kalbach Anne, Cristofalo Vincent J, Gocke Christopher D
Abstract excerpt
Multibase deletions in mitochondrial DNA (mtDNA) have been shown to accumulate with age in several tissues, including skin, whereas point mutations have only recently been demonstrated to increase during aging, with several specific mutations occurring at high levels (up to 50%) in skin fibroblasts obtained from old donors [Science 286(1999)774]. We have conducted a survey for a specific deletion and for point...
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