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Article

beta-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas.

Cancer science - 1 Dec 2003

Tsukamoto Tetsuya, Yamamoto Masami, Ogasawara Naotaka, Ushijima Toshikazu, Nomoto Tomoko, Fujita Hirofumi, Matsushima Taijiro, Nozaki Koji, Cao Xueyuan, Tatematsu Masae

Abstract excerpt

Aberrant Wnt/beta-catenin signaling caused by mutations in exon 3 of the beta-catenin gene has been identified in a number of human malignancies, including stomach cancer. However, studies of mutation frequency have yielded conflicting results, and timing during progression remains largely unknown. In this study, we utilized an animal model to address this question. A total of 20 ACI male rats were treated with...

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Identifiers

PMID: 14662019
DOI: 10.1111/j.1349-7006.2003.tb01399.x
PMCID: PMC11160191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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