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Article

Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation.

The American journal of surgical pathology - 1 Dec 2009

Yachida Shinichi, Mudali Shiyama, Martin Sherri A, Montgomery Elizabeth A, Iacobuzio-Donahue Christine A

Abstract excerpt

Recent observations indicate that some sessile serrated adenomas (SSAs) have aberrant beta-catenin nuclear labeling, implicating the Wnt pathway in the molecular progression of SSAs to colorectal carcinoma. We sought to expand upon this finding by characterizing beta-catenin expression in the full spectrum of serrated colorectal polyps, and correlating these findings with the genetic status of BRAF, KRAS and...

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Topics

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Share to Adenoma
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 19745699
DOI: 10.1097/PAS.0b013e3181b6da19
PMCID: PMC2788075

Genes

BRAF
CTNNB1
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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