Article
Rearrangements of chromosome bands 15q12-q21 are secondary to HMGA2 deregulation in conventional lipoma.
Oncology reports - 1 Feb 2014
Macchia Gemma, Nord Karolin H, D'Alessandro Giuseppina, Nilsson Jenny, Magnusson Linda, Mandahl Nils, Storlazzi Clelia Tiziana, Mertens Fredrik
Abstract excerpt
Rearrangements of chromosome arm 15q are rare but recurrent in conventional lipomas, a tumor type often showing deregulated expression of the HMGA2 gene. In order to assess whether 15q rearrangements could constitute a distinct pathogenetic mechanism, we studied seven cases of conventional lipoma that at G-banding analysis had various rearrangements of 15q12-q21. The breakpoints in 15q were mapped by fluorescence...
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