Article
The recipient CYP2D6 allele 4-associated poor metabolizer status correlates with an early fibrosis development after liver transplantation.
Transplant international : official journal of the European Society for Organ Transplantation - 1 Nov 2011
Zimmermann Tim, Hoppe-Lotichius Maria, Körner Andreas, Lautem Anja, Heise Michael, Foltys Daniel, Weiler Nina, Biesterfeld Stefan, Schmidtmann Irene, Galle Peter R, Otto Gerd, Schuchmann Marcus
Abstract excerpt
CYP2D6 is part of the cytochrome P450 system, which catalyzes biotransformation of endogenous substrates and xenobiotics. Approximately 10% of the Caucasian population has two null alleles, resulting in a poor metabolizer (PM) status. Mostly, allele four (CYP2D6*4) is responsible for the PM status, which is suspected to be associated with an accelerated fibrosis progression (FP). The aim of the present study was...
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