Article
[Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica - 1 Jul 1998
Yokoi T, Kamataki T
Abstract excerpt
Interindividual variation of drug effects in humans can be attributed to many factors. Among the factors, the rate of drug metabolism has been regarded as the most important one. A genetic defect of enzymes involved in drug metabolism, particularly cytochrome P450 (CYP), has been believed to be o...
Topics
- Alleles
- Animals
- Aryl Hydrocarbon Hydroxylases
- Asian People
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Genotype
- Humans
- Japan
- Mixed Function Oxygenases
- Mutation
- Phenotype
- Platelet Aggregation Inhibitors
- Polymorphism, Genetic
- Substrate Specificity
- Thiazoles
- Thiazolidines