Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of cyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: analysis of allele-specific expression.

Genes, chromosomes & cancer - 1 May 1998

Hosokawa Y, Arnold A

Abstract excerpt

The cyclin D1/CCND1 oncogene (PRAD1) is amplified in 15% of primary human breast cancers and overexpressed in 30-50% of breast cancers, suggesting that mechanisms in addition to DNA amplification may lead to deregulated expression of this gene in breast cancer. Cyclin D1 overexpression at a higher frequency than gene amplification is also seen in a variety of other tumors. Cyclin D1 overexpression without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Breast Neoplasms
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Gene Expression Regulation, Neoplastic

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9591636
DOI: 10.1002/(sici)1098-2264(199805)22:1<66::aid-gcc9>3.0.co;2-5

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of cyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: analysis of allele-specific expression.PMID 9591636Read ↗

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.Semantic proximity Read ↗

Cyclin D1 gene (CCND1) mutations in endometrial cancer.Semantic proximity Read ↗

Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer.Semantic proximity Read ↗

Function of a human cyclin gene as an oncogene.Semantic proximity Read ↗

Polymorphisms in cyclin D1 gene and hepatocellular carcinoma.Semantic proximity Read ↗

Molecular alterations associated with cyclin d1 overexpression in endometrial cancerSemantic proximity Read ↗

Analysis of cyclin D1 (CCND1) allelic imbalance and overexpression in sporadic human pituitary tumors.Semantic proximity Read ↗

Cell cycle‐related variation and tissue‐restricted expression of human cyclin D1 proteinSemantic proximity Read ↗

The PRAD‐1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomasSemantic proximity Read ↗

Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinomaSemantic proximity Read ↗

Cyclin D1 protein expression and gene polymorphism in colorectal cancer. Aberdeen Colorectal Initiative.Semantic proximity Read ↗

Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.