Function of a human cyclin gene as an oncogene.

doi:10.1073/pnas.91.2.709

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Function of a human cyclin gene as an oncogene.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994

Hinds P W, Dowdy S F, Eaton E N, Arnold A, Weinberg R A

Abstract excerpt

The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribu...

Topics

Adenovirus E1A Proteins
Alleles
Amino Acid Sequence
Animals
Cell Line, Transformed
Cell Transformation, Neoplastic
Cells, Cultured
Cyclin D1
Cyclins
Defective Viruses
Genes, Viral
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutation

Oncogene Proteins

Oncogenes

Rats

Source

Open in PubMed Open full text

Identifiers

PMID: 8290586
DOI: 10.1073/pnas.91.2.709
PMCID: PMC43018

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8290586-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Function of a human cyclin gene as an oncogene.PMID 8290586Read ↗

Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expressionSemantic proximity Read ↗

An update on the implications of cyclin D1 in oral carcinogenesisSemantic proximity Read ↗

Cyclins and Cell Cycle Control in Cancer and DiseaseSemantic proximity Read ↗

Cyclin D1 and human neoplasiaSemantic proximity Read ↗

Cyclin D1 Determines Mitochondrial Function InVivoSemantic proximity Read ↗

Proteomic Identification of a Direct Role for Cyclin D1 in DNA Damage RepairSemantic proximity Read ↗

Cyclin D1 protein expression and function in human breast cancerSemantic proximity Read ↗

A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human CancerSemantic proximity Read ↗

Overexpression of Cyclin D1 Occurs Frequently in Human Pancreatic Endocrine Tumors1Semantic proximity Read ↗

Genomic organization, chromosomal localization, and independent expression of human cyclin D genesSemantic proximity Read ↗

Human D-type cyclinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.