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Article

Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer.

British journal of cancer - 1 Feb 1996

Betticher D C, Heighway J, Hasleton P S, Altermatt H J, Ryder W D, Cerny T, Thatcher N

Abstract excerpt

Amplification of the CCDN1 gene encoding cyclin D1 was examined by Southern blotting and multiplex polymerase chain reaction (PCR) and occurred in 8 of 53 patients (15%) with primary resected non-small-cell lung cancer (NSCLC). These tumours and 17 additional tumours with a normal gene copy number showed overexpression of cyclin D1 (25/53, 47%), as assessed by immunostaining using a monoclonal antibody. In 22/25...

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Source

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Identifiers

PMID: 8562333
DOI: 10.1038/bjc.1996.52
PMCID: PMC2074441

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer.PMID 8562333Read ↗

Cyclin D1 overexpression in bronchial epithelia of patients with lung cancer is associated with smoking and predicts survival.Semantic proximity Read ↗

Association of CCND1 overexpression with KRAS and PTEN alterations in specific subtypes of non-small cell lung carcinoma and its influence on patients' outcome.Semantic proximity Read ↗

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Functional role of CyclinD1 polymorphism (G870A) in modifying susceptibility and overall survival of North Indian lung cancer patients.Semantic proximity Read ↗

G1 control gene status is frequently altered in resectable non-small cell lung cancer.Semantic proximity Read ↗

CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer.Semantic proximity Read ↗

Effects of the cyclin D1 polymorphism on lung cancer risk--a meta-analysis.Semantic proximity Read ↗

Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinomaSemantic proximity Read ↗

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Effects of cyclin D1 (CCND1) polymorphism on susceptibility to lung cancer in a North Indian population.Semantic proximity Read ↗

Cyclin D1 polymorphism in non-small cell lung cancer in a Portuguese population.Semantic proximity Read ↗

Association between CCND1 G/A870 polymorphism, allele-specific amplification, cyclin D1 expression, and survival in esophageal and lung carcinoma.Semantic proximity Read ↗

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