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Article

The PRAD‐1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas

15 Aug 1994

Abstract excerpt

The PRAD-1/cyclin D1 proto-oncogene is localized on chromosome 11q13 and it is overexpressed in several tumour types as a consequence of gene amplification or chromosomal rearrangements. In this study, the abundance and patterns of cyclin D1 protein expression in normal/non-involved colon (n = 44), primary (n = 48) and metastatic (n = 9) colorectal carcinomas, and in a series of 4 colon cancer cell lines were...

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PMID: 8056453
DOI: 10.1002/ijc.2910580420

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