Article
Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.
The New England journal of medicine - 17 Mar 1994
Cryns V L, Thor A, Xu H J, Hu S X, Wierman M E, Vickery A L, Benedict W F, Arnold A
Abstract excerpt
BACKGROUND: The origin and molecular pathogenesis of parathyroid carcinoma are unknown. This life-threatening cause of primary hyperparathyroidism cannot be reliably distinguished from its benign counterpart on the basis of histopathological features alone. Because the PRAD1, or cyclin D1, gene, a cell-cycle regulator, has been implicated in a subgroup of benign parathyroid tumors, we examined the possibility...
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