Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.

doi:10.1056/NEJM199403173301105

Back to search

Article

Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.

The New England journal of medicine - 17 Mar 1994

Cryns V L, Thor A, Xu H J, Hu S X, Wierman M E, Vickery A L, Benedict W F, Arnold A

Abstract excerpt

BACKGROUND: The origin and molecular pathogenesis of parathyroid carcinoma are unknown. This life-threatening cause of primary hyperparathyroidism cannot be reliably distinguished from its benign counterpart on the basis of histopathological features alone. Because the PRAD1, or cyclin D1, gene,...

Topics

Adenoma
Adult
Aged
Alleles
Carcinoma
Female
Gene Deletion
Genes, Retinoblastoma
Humans
Male
Middle Aged
Parathyroid Neoplasms
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Retinoblastoma Protein

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.