Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

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Article

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

Cancer research - 1 Apr 1994

Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Peters G

Abstract excerpt

Immunohistochemical staining with a monoclonal antibody against human cyclin D1 can be used to identify breast cancers that have an amplification of the q13 region of chromosome 11. In general, the intensity of staining is directly proportional to the degree of DNA amplification. In two unusual tumors, in which the CCND1 locus is highly amplified but staining is relatively weak, it appears that the DNA has...

Topics

Alleles
Antibodies, Monoclonal
Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 11
Cyclin D1
Cyclins
DNA, Neoplasm
Female
Gene Amplification
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunohistochemistry

Oncogene Proteins

Prognosis

RNA, Neoplasm

Transcription, Genetic

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8137296

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8137296-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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