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Article

Long-read sequencing of CYP2D6 may improve psychotropic prescribing and treatment outcomes: A systematic review and meta-analysis.

Journal of psychopharmacology (Oxford, England) - 1 Sept 2024

Kaptsis Dean, Lewis Martin, Sorich Michael, Battersby Malcolm

Abstract excerpt

BACKGROUND: The enzyme expression (i.e. phenotype) of the Cytochrome P450 2D6 (CYP2D6) gene is highly relevant to the metabolism of psychotropic medications, and therefore to precision medicine (i.e. personalised prescribing). AIMS: This review aims to assess the improvement in CYP2D6 phenotyping sensitivity (IPS) and accuracy (IPA) offered by long-read sequencing (LRS), a new genetic testing technology. METHODS:...

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Identifiers

PMID: 39262167
DOI: 10.1177/02698811241268899
PMCID: PMC11447996

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