Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How to overcome resistance of influenza A viruses against adamantane derivatives.

Antiviral research - 1 Feb 1998

Scholtissek C, Quack G, Klenk H D, Webster R G

Abstract excerpt

We tested two approaches to overcoming resistance of influenza A viruses against adamantane derivatives. First, adamantane derivatives that interfere with the ion channel function of the variant M2 protein of amantadine-resistant viruses may prevent drug resistance, if they are used in mixture with amantadine. Second, amantadine acts on the M2 protein (at low concentrations) and indirectly on the hemagglutinin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Chick Embryo
Share to Dogs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Genetic Variation

Share to Hydrogen-Ion Concentration

Share to Molecular Structure

Share to Virus Replication

Source

Identifiers

PMID: 9588841
DOI: 10.1016/s0166-3542(97)00061-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How to overcome resistance of influenza A viruses against adamantane derivatives.PMID 9588841Read ↗

Adamantane-resistant influenza a viruses in the world (1902-2013): frequency and distribution of M2 gene mutations.Semantic proximity Read ↗

The genesis and spread of reassortment human influenza A/H3N2 viruses conferring adamantane resistance.Semantic proximity Read ↗

[Rapid method of producing influenza A virus variants resistant to amantadine and remantadine and their primary characteristics].Semantic proximity Read ↗

Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States.Semantic proximity Read ↗

Surveillance of Resistance to Adamantanes among Influenza A(H3N2) and A(H1N1) Viruses Isolated WorldwideSemantic proximity Read ↗

Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2S31N-based drug resistance.Semantic proximity Read ↗

Amantadine-resistant influenza A (H3N2) viruses in Iran.Semantic proximity Read ↗

Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008.Semantic proximity Read ↗

Resistance characteristics of influenza to amino-adamantyls.Semantic proximity Read ↗

Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants.Semantic proximity Read ↗

The origin and global emergence of adamantane resistant A/H3N2 influenza virusesSemantic proximity Read ↗

How do aminoadamantanes block the influenza M2 channel, and how does resistance develop?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.