Article
How to overcome resistance of influenza A viruses against adamantane derivatives.
Antiviral research - 1 Feb 1998
Scholtissek C, Quack G, Klenk H D, Webster R G
Abstract excerpt
We tested two approaches to overcoming resistance of influenza A viruses against adamantane derivatives. First, adamantane derivatives that interfere with the ion channel function of the variant M2 protein of amantadine-resistant viruses may prevent drug resistance, if they are used in mixture wi...
Topics
- Adamantane
- Animals
- Antiviral Agents
- Cell Line
- Chick Embryo
- Dogs
- Drug Resistance, Microbial
- Genetic Variation
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemolysis
- Humans
- Hydrogen-Ion Concentration
- Influenza A virus
- Molecular Structure
- Viral Matrix Proteins
- Virus Replication