Article
Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008.
Influenza and other respiratory viruses - 1 Nov 2009
Deyde Varough, Garten Rebecca, Sheu Tiffany, Smith Catherine, Myrick Allison, Barnes John, Xu Xiyan, Shaw Michael, Klimov Alexander, Gubareva Larisa
Abstract excerpt
BACKGROUND: Adamantanes resistance in H3N2 viruses has been increasing since 2000, and in 2005-2006 reached nearly 100% in most countries, with the circulation of the N-lineage. In 2006-2007, however, a significant decrease in resistance was observed in many regions. OBJECTIVES: To explore potential links between adamantane resistance and the A(H3N2) viruses that circulated between 2006 and 2008. METHODS: A total...
Topics
- Adamantane
- Antiviral Agents
- Cluster Analysis
- Drug Resistance, Viral
- Genome, Viral
- Genotype
- Humans
- Influenza A Virus, H3N2 Subtype
- Influenza, Human
- Phylogeny
- RNA, Viral
- Sequence Analysis, DNA
- Sequence Homology