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Article

How do aminoadamantanes block the influenza M2 channel, and how does resistance develop?

Journal of the American Chemical Society - 29 Jun 2011

Leonov Hadas, Astrahan Peleg, Krugliak Miriam, Arkin Isaiah T

Abstract excerpt

The interactions between channels and their cognate blockers are at the heart of numerous biomedical phenomena. Herein, we unravel one particularly important example bearing direct pharmaceutical relevance: the blockage mechanism of the influenza M2 channel by the anti-flu amino-adamantyls (amantadine and rimantadine) and how the channel and, consequently, the virus develop resistance against them. Using both...

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PMID: 21534619
DOI: 10.1021/ja202288m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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