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Article

Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants.

Antiviral research - 1 Jul 2006

Ilyushina Natalia A, Bovin Nicolai V, Webster Robert G, Govorkova Elena A

Abstract excerpt

Rapid development of resistant influenza variants after amantadine treatment is one of the main drawbacks of M2 blockers. On the other hand, the emergence of variants with low susceptibility to the neuraminidase (NA) inhibitors is limited. In the present study we examined whether combination therapy with two classes of anti-influenza drugs can affect the emergence of resistant variants in vitro. We observed that...

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PMID: 16516984
DOI: 10.1016/j.antiviral.2006.01.012

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