Article
The genesis and spread of reassortment human influenza A/H3N2 viruses conferring adamantane resistance.
Molecular biology and evolution - 1 Aug 2007
Simonsen Lone, Viboud Cécile, Grenfell Bryan T, Dushoff Jonathan, Jennings Lance, Smit Marita, Macken Catherine, Hata Mami, Gog Julia, Miller Mark A, Holmes Edward C
Abstract excerpt
A dramatic rise in the frequency of resistance to adamantane drugs by influenza A (H3N2) viruses has occurred in recent years -- from approximately 2% to approximately 90% in multiple countries worldwide-and associated with a single S31N amino acid replacement in the viral matrix M2 protein. To explore the emergence and spread of these adamantane resistant viruses we performed a phylogenetic analysis of recently...
Topics
- Adamantane
- Amino Acid Substitution
- Antiviral Agents
- Asia
- Australia
- Biological Assay
- Drug Resistance, Viral
- Evolution, Molecular
- Genetic Variation
- Genome, Viral