A mechanism for unsplicing and exon skipping in human alpha- and beta-globin mutant pre-mRNA splicing.

Article

A mechanism for unsplicing and exon skipping in human alpha- and beta-globin mutant pre-mRNA splicing.

Nucleic acids symposium series - 1 Jan 1997

Iida Y

Abstract excerpt

In both of normal human alpha- and beta-globin pre-mRNAs, two introns are spliced correctly, giving mRNA products of (exon 1)-(exon 2)-(exon 3). If 5'-splice site of the second intron is mutated, mRNA of the beta-globin is composed of (exon 1)-(exon 3), skipping the whole exon 2 sequence. However...

Topics

Base Sequence
Exons
Globins
Humans
Introns
Mutation
Oligodeoxyribonucleotides
RNA Precursors
RNA Splicing
Recombinant Fusion Proteins

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