Quantification analysis of 5'-splice signal sequences in mRNA precursors. Mutations in 5'-splice signal sequence of human beta-globin gene and beta-thalassemia.

doi:10.1016/s0022-5193(05)80486-2

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Article

Quantification analysis of 5'-splice signal sequences in mRNA precursors. Mutations in 5'-splice signal sequence of human beta-globin gene and beta-thalassemia.

Journal of theoretical biology - 23 Aug 1990

Iida Y

Abstract excerpt

Concerning the signals which direct excision of introns from mRNA precursors in higher eukaryotic genes, consensus 9-nucleotide sequence, (CA)AG/GT(AG)AGT, has been proposed with the 5'-splice site, but actual 5'-splice site sequences differ from it in a greater or lesser degree. We analyzed 5'-s...

Topics

Base Sequence
Globins
Humans
Models, Genetic
Molecular Sequence Data
Mutation
RNA Precursors
RNA Splicing
Thalassemia

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